2021-2022年南京地区儿童特异性过敏原定量检测分析及其临床价值
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南京医科大学科技发展基金( NMUB2020096)


Quantitative detection and clinical value of allergens in children of Nanjing area from 2021 to 2022
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    摘要:目的探讨2021-2022年南京地区过敏性疾病患儿过敏原的分布和规律,为儿童过敏性疾病的预防和治疗提供科学依据。方法对2021年1月至2022年12月在南京医科大学附属儿童医院进行过敏原检测的8 855例患儿结合性别、年龄、季节和临床诊断进行统计分析。结果8 855例患儿血清sIgE阳性率为59.87%。 食入性过敏原阳性检出率前3位依次为牛奶(35.00%)、蛋白(34.00%)和坚果混合(13.19%);吸入性过敏原阳性检出率前3位依次为户尘蟎(28.28%)、粉尘螨( 27.56%)和霉菌混合(23.50%)。除牛奶和狗毛屑外,男孩其他过敏原sIgE阳性率均高于女孩(P<0.05)。3岁以下患儿以食入性过敏原为主,牛奶、蛋白是主要的过敏原;3岁以上患儿则以吸入性过敏原为主,户尘螨、粉尘蟎和霉菌混合是主要的过敏原。吸入性过敏原夏季阳性率最高,冬季阳性率最低,除猫皮屑、狗毛屑及德国小蠊(蟑螂)外,其余过敏原阳性率在各季节之间的差异有统计学意义(P<0.05)。食入性过敏原常引起患儿皮肤及消化系统问题;吸入性过敏原多累及患儿呼吸系统。结论南京地区常见的过敏原是牛奶、蛋白、 尘螨及霉菌混合,不同性别、年龄、季节及疾病的过敏原均存在一定差异。合理、精准检测过敏原可以为患儿提供预防和护理依据,并为临床提供诊疗参考。

    Abstract:

    Abstract : Objective To explore the distribution and patterns of allergens in children with allergies in Nanjing from 2021 to 2022,and then provide scientific basis for the prevention and treatment of allergic diseases in children. Methods The data of 8855 children with allergies in the Children's Hospital Afiliated to Nanjing Mediceal University from January 2021 to December 2022 were statistically analyzed in combination with gender, age, season and clinical diagnosis. Results The positive rate of serum sIgE in 8 855 children was 59.87%. Milk (35.00%), egg albumin (34.00%), and nut mixture (13.19%) were the top three of food allergens. The top three of inhalation alergens were dermatophagoides pteronyssinus ( 28. 28%),dermatophagoides farinae ( 27. 56%),and mixed mold (23.50% ). Except for milk and dog dander, the positive rates of serum sIgE for other allergens in boys were significantly higher than that in gidls ( P<0.05). The children under 3 years old were mainly allergic to food allergens. Milk and egg albumin were the main allergens. The children over 3 years old were mainly alegic to inhalation allergens and dermatophagoides pteronyssinus, dermatophagoides farinae,and mixed mold were the main allergens. The positive rates of inhaled allergens were the highest in summer and the lowest in winter. There were stat itically significant differences in the positivity rates of other allergens among different seasons, except for cat dander, dog dander, and German cockroaches ( P <0.05). Ingestive allergens often cause skin and digestive system problems in children and inhalation allergens often involve the respiratory system of children. Conclusion The common allergens in Nanjing are milk, egg albumin, dust mites, and mixed mold. There are some differences in allergens among diferent genders ,ages, seasons and diseases. Reasonable and accurate detection of allergens can provide prevention and nursing basis for children and reference for clinical diagnosis and treatment.

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金菲,高岭,杨大恒,朱纯亮.2021-2022年南京地区儿童特异性过敏原定量检测分析及其临床价值[J].临床检验杂志,2024,42(003):226-230

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  • 收稿日期:2023-07-07
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  • 在线发布日期: 2024-05-09
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