Objective To investigate the value of tissue plasminogen activator-inhibitor 1 complex (t-PAIC) in judging the prognosis of patients with sepsis-induced coagulopathy (SIC). Methods The clinical data of 91 patients with SIC from the Intensive Care Unit of the 908th Hospital during May 2018 and October 2020 were retrospectively analyzed. The patients were divided into the survival group (n=49) and death group (n=42) according to the prognosis on the 90th day, and the differences in baseline characteristics and coagulation markers between the two groups were compared and statistically analyzed. Results The levels of blood thrombomodulin (TM) and t-PAIC in the survival group were significantly higher than that in the death group (P＜0.05). The results of Logistic regression analysis showed that t-PAIC was the independent risk factor of death in SIC patients. The receiver operating characteristic (ROC) curve analysis showed that the areas under the ROC curve of t-PAIC, sequential organ failure assessment (SOFA), acute physiology and chronic health evaluation Ⅱ (APACHEⅡ), t-PAIC combined with SOFA and t-PAIC combined with APACHEⅡ were 0.722, 0.677, 0.647, 0.740 and 0.713, respectively. When the cut-off value of t-PAIC was 18 ng/mL, the sensitivity, specificity, positive predictive value and negative predictive value of t-PAIC in judging the prognosis of SIC patients were 78.6%, 59.2%, 63.1% and 75.3%, respectively. Survival analysis showed that the death risk of patients with t-PAIC＞18 ng/mL was 3.236 times higher than that with t-PAIC≤18 ng/mL. Conclusion t-PAIC has high value in judging the prognosis of SIC patients.