Objective?To explore the clinical diagnostic value of preimplantation genetic testing（PGT）for the families with ring chromosome carriers.Methods?A patient with ring chromosome 22 in peripheral blood karyotype detected in the Affiliated Reproduction Hospital of Shandong University was assisted with PGT based on the next generation sequencing（NGS）.The selected embryos without abnormal karyotype were implanted，and the progeny chromosome was confirmed by prenatal examination.Results?The patient underwent 2 ovulation induction cycles，and 5 embryos were tested by PGT，among which 3 embryos were diagnosed as aneuploidy and 2 embryos showed no abnormality.Live birth was obtained after implantation of the embryos with normal phenotype.The results of prenatal amniocentesis were 46，XN，r（22）（p11.2q13）.Conclusion?The rate of aneuploidy may increase in the embryos of carriers with ring chromosomes.The aneuploidy embryos can be excluded by PGT detection and normal progeny could be obtained.However，the inheritance of annular chromosomes to progeny could not be blocked by current PGT technology.